Intra‐ and inter‐chromosomal interactions correlate with CTCF binding genome wide
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چکیده
منابع مشابه
Intra- and inter-chromosomal interactions correlate with CTCF binding genome wide
A prime goal in systems biology is the comprehensive use of existing high-throughput genomic datasets to gain a better understanding of chromatin organization and genome function. In this report, we use chromatin immunoprecipitation (ChIP) data that map protein-binding sites on the genome, and Hi-C data that map interactions between DNA fragments in the genome in an integrative approach. We fir...
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CTCF is a transcription factor with highly versatile functions ranging from gene activation and repression to the regulation of insulator function and imprinting. Although many of these functions rely on CTCF-DNA interactions, it is an emerging realization that CTCF-dependent molecular processes involve CTCF interactions with other proteins. In this study, we report the association of a subpopu...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2010
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb.2010.79